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Market

Celiac Disease

  • Celiac disease is an autoimmune disease that is triggered by consuming gluten and results in damage to the small intestine
  • Symptoms include diarrhea, fatigue, headaches, anemia, nausea, dermatitis herpetiformis (itchy skin rash)
  • Significant patient population does not respond to gluten free diets
  • Health consequences for not treating include malnourishment, cancer and other autoimmune conditions
  • Estimated prevalence is 1:133 (2.5 million people) with celiac disease in the US (Fasano, Arch Intern Med. 2003 PMID: 12578508)
  • 0.3% to 0.5% of celiac disease patients are non-responsive (Malamut Gastroenterology. 2024 38556189)
  • There are no approved treatment options for celiac disease
  • It has been estimated by various U.S. advocacy and epidemiology sources that up to 80% of people in the U.S. with celiac disease are undiagnosed

Vitiligo

  • Vitiligo is an autoimmune disease of the skin mediated primarily by NK and CD8+ T cells that attack melanocytes leading to patchy depigmentation of the skin
  • It is estimated that vitiligo affects 2 million people in the U.S (NIH)
  • The global vitiligo treatment market size was estimated at $1.6-1.8 billion in 20124-2025 and is projected to reach $2.3-2.7 billion by 2032-2034 (Fortune Business Insights)

Type 1 Diabetes

  • Type 1 diabetes (T1D) is classified by three stages of progression
  • Stage 1: At least one diabetes-related autoantibody but has normal blood sugar and no symptoms
  • Stage 2: At least two diabetes-related autoantibodies and abnormal blood sugar levels but otherwise symptom free
  • Stage 3: Significant beta cell loss has occurred; abnormal blood sugar levels; hemoglobin A1C >6.4%; excessive thirst and urination; blurry vision; fatigue; requires insulin for disease management
  • 64,000 people diagnosed with Type 1 diabetes annually (https://beyondtype1.org/type-1-diabetes-statistics/)
  • 2 approved treatment options to delay the onset of Type 1 diabetes

Alopecia Areata (AA)

  • AA is an autoimmune disease in which immune cells attack and damage hair follicles and is mediated primarily by CD8+ T cells and NK cells
  • The global alopecia treatment market has been valued at around $3-3.5 billion in 2024 with some forecasts pointing to $6 billion in 20232-2034 (DataM Intelligence)